Tris Acetate Material Safety Data Sheet (MSDS)

Identification

Product Name: Tris Acetate
Synonyms: Tris(hydroxymethyl)aminomethane acetate, 2-Amino-2-(hydroxymethyl)-1,3-propanediol acetate
Chemical Formula: C4H11NO3·C2H4O2
CAS Number: 6131-90-4
Recommended Uses: Laboratory reagent, buffer in biological research and molecular biology
Supplier Information: Company name, street address, phone number, emergency contact
Emergency Phone: Contact number for spill, fire, or medical emergencies
Prepared By: Safety officer name, date of preparation
Email for Safety Issues: Provided safety contact email address

Hazard Identification

Hazard Classification: Not classified as hazardous under GHS
Label Elements: None required due to low hazard level
Hazard Statements: May cause mild irritation to eyes and skin if handled improperly
Precautionary Statements: Avoid direct contact with eyes or skin, do not ingest, wash hands after handling
Other Hazards: May cause minor discomfort if inhaled as dust, not considered carcinogenic, mutagenic, or toxic for reproduction
Signal Word: None mandated
Emergency Overview: White crystalline powder, essentially odorless

Composition / Information on Ingredients

Chemical Name: Tris(hydroxymethyl)aminomethane
Common Name: Tris
Concentration/Range: 90-100%
Impurities: Not significant for hazard classification
EC Number: 222-720-6
Molecular Weight: 165.19 g/mol
Component Identification: No hazardous components present above relevant thresholds

First Aid Measures

Eye Contact: Flush eyes with plenty of water for at least 15 minutes, lift eyelids occasionally, seek medical attention if irritation persists
Skin Contact: Wash affected area with soap and plenty of water, remove contaminated clothing, seek attention if redness or rash develops
Inhalation: Move person to fresh air, monitor for respiratory distress, seek medical attention if symptoms develop
Ingestion: Rinse mouth with water, do not induce vomiting, give small amounts of water if conscious, obtain medical aid if unwell
Most Important Symptoms: Mild irritation, redness, itching, accidental ingestion may cause mild gastrointestinal upset

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide, avoid high-pressure water streams
Unsuitable Extinguishing Media: None known
Specific Hazards: Combustion may produce nitrogen oxides, carbon monoxide, carbon dioxide
Protective Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus
Special Procedures: Cool exposed containers with water spray to prevent rupture
Hazardous Combustion Products: Possible release of irritating or toxic fumes under fire conditions

Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, use protective gloves, goggles, lab coats
Respiratory Precautions: Use dust mask or respirator if significant dust generation occurs
Environmental Precautions: Do not allow material to enter drains or surface water, minimize release to the environment
Spill Clean-Up Methods: Sweep up with minimal dust generation, transfer to a labeled container for proper disposal, wash spill site with water once cleaned
Containment: Prevent further leakage or spillage if safe to do so
Reference to Other Sections: Refer to sections on Personal Protection and Disposal

Handling and Storage

Handling Practices: Avoid breathing dust, minimize dust generation, use in well-ventilated areas, avoid contact with skin, eyes, and clothing, wash hands thoroughly after use
Storage Conditions: Store in cool, dry, well-ventilated area away from incompatible materials, keep container tightly closed when not in use
Incompatible Materials: Strong oxidizers, strong acids
Specific Uses: Laboratory chemical, buffer applications
Hygiene Practices: Remove contaminated clothing and wash before reuse, do not eat, drink, or smoke during use

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits
Engineering Controls: Ensure adequate ventilation, use fume hood if available
Personal Protective Equipment: Safety glasses or goggles, lab coat, protective gloves (nitrile or latex), dust mask or NIOSH-approved respirator if dust becomes airborne
Skin Protection: Use protective gloves and clothing to prevent skin exposure
Eye/Face Protection: Use safety glasses with side shields as a minimum
Respiratory Protection: Use appropriate respirator if dust generation is significant or if exposure limits are exceeded
Other Protection: Emergency eyewash stations and safety showers should be available where this chemical is used

Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 7.0–9.0 (1% solution in water)
Melting Point: 172–175°C (decomposes)
Boiling Point: Not applicable
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not applicable
Flammability: Not considered to present a fire or explosion hazard
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Solubility in Water: Freely soluble
Partition Coefficient (n-octanol/water): Not determined
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Above 172°C
Viscosity: Not applicable
Relative Density: 1.35 at 20°C

Stability and Reactivity

Chemical Stability: Chemically stable under recommended storage conditions
Reactivity: Not known for hazardous reactivity in standard laboratory environments
Possibility of Hazardous Reactions: No hazardous polymerization expected
Conditions to Avoid: Excessive heat, moisture, sources of ignition
Incompatible Materials: Strong acids, strong oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides

Toxicological Information

Acute Toxicity: Low acute toxicity, not expected to cause harmful health effects at low doses
Routes of Exposure: Inhalation, ingestion, skin or eye contact
Potential Health Effects: Slight irritation to eyes, skin, and respiratory tract on contact; ingestion may cause minor gastrointestinal discomfort
Symptoms: Redness, itching, mild pain in exposed tissues
Sensitization: Not classified as a sensitizer
Chronic Effects: No evidence of chronic health impacts or sensitization
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity: Not expected
Reproductive Toxicity: No evidence in available studies
LD50 (Oral, Rat): Above 7000 mg/kg, showing very low toxicity

Ecological Information

Toxicity to Aquatic Life: Not expected to be hazardous to aquatic environments in low concentrations
Persistence and Degradability: Readily biodegradable in water; undergoes microbial degradation
Bioaccumulation Potential: No potential for bioaccumulation observed
Mobility in Soil: High mobility in water, not expected to persist in soil
Other Adverse Effects: Not classed as dangerous to the environment based on available data
Additional Information: Avoid large releases to prevent local disturbance

Disposal Considerations

Disposal Methods: Place in tightly closed, labeled container for chemical waste, follow all local, regional, and national regulations
Contaminated Packaging: Rinse container before disposal, dispose of as non-hazardous chemical waste
Special Precautions: Prevent material from entering sewers or waterways, use professional waste disposal services as appropriate
Regulatory Waste Code: Not classified as hazardous waste in most jurisdictions

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class(es): Does not pose transport hazard
Packing Group: Not applicable
Environmental Hazards: Not considered hazardous for transport purposes
Special Precautions for User: Transport in accordance with local, state, and federal regulations; avoid mechanical impact that may cause damage to packaging
DOT, IATA, IMDG Status: Not regulated as dangerous goods
Other Transport Information: Secure containers to prevent movement during transit

Regulatory Information

Safety, Health, and Environmental Regulations: Not subject to specific regulations under OSHA, TSCA, SARA, or CERCLA
Labelling Requirements: No special labelling required for workplace or public sale
Other National Requirements: Comply with individual country chemical inventory requirements
International Inventories: Listed on US TSCA, Canada DSL/NDSL, EU EINECS/ELINCS, Australia AICS, Japan ENCS, South Korea KECI
Workplace Safety: Follow standard chemical hygiene practices regardless of regulatory exemption
REACH Registration Number: Not required for substances supplied in small quantities for research or teaching
Further Information: Review workplace-specific risk assessments for handling procedures depending on use